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Methadone may perhaps result in extreme hypotension such as orthostatic hypotension and syncope in ambulatory clients. Check throughout initiation and/or titration of methadone.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​â€